Darmflora aka Microbiome
There is a community of 38,000,000,000,000,000 microorganisms that live in and on us. Amazingly, from a scientific point of view, we are only 50% human, because bacteria make up the other half of you in terms of cell count. The majority of all cells in the human body are bacteria. And what do these do? They regulate your digestion and provide you with essential vitamins.
A synbiotic is a combination of prebiotics and probiotics. Probiotics represent selected bacterial cultures. Prebiotics, on the other hand, consist of indigestible biomolecules, which serve as a food source for the beneficial bacterial cultures.
Scientific Advisory Board
Prof. dr. med. Wolfgang Meyer-Sabelleck
Prof. Dr. medical Wolfgang Meyer-Sabelleck is a doctor, manager and university lecturer. He was and is still active for numerous scientific institutions as an expert and advisor. He is also the author and co-author of more than 300 scientific publications.
Dr. Med. Neha is her
Neha is a doctor based in London and spent years as a general practitioner before moving into the life sciences industry where she has held various roles in pharmaceutical companies. She has an MBA from London Business School where she fell in love working with entrepreneurs and startups.
Dipl. -At. Dr. rrr. nat. Patrick Scholler
dr Patrik Schiller is a qualified engineer. He studied (bio)chemistry at the Technical University of Darmstadt and did his doctorate in molecular genetics at the German Cancer Research Center in Heidelberg.
Dipl. Biochem. Dr. rer. hum. biol. Thomas Borcholte
dr Thomas Borcholte is a graduate biochemist and received his doctorate in human biology in 1987 from the MHH Medical University in Hanover. In his career, Dr. Borcholte held various international management positions in the pharmaceutical and biotech industry as well as in the event business.
dr medical Wolfgang Graef
dr medical Wolfgang Gräf is a passionate sports physician and has over 30 years of experience as a doctor. During his medical career he dealt intensively with the performance of professional athletes.
Our digestive system, with its beneficial intestinal bacteria, ensures that our food is digested and thereby provides us with energy. But there are often problems here that can limit the quality of life and that people do not like to talk about. A common topic is irritable bowel syndrome, which causes unpleasant symptoms in the intestines in many people. In the case of irritable bowel syndrome, no “pathophysiologically” explainable causes can be found at the present time. However, studies have shown that some probiotics are effective in reducing symptoms and pain1,12,13,14,15. Another common symptom (particularly more common in older people) is constipation, i.e. an excessively hard stool or frequent and painful constipation. Studies with bacterial strains that are also contained in the Dailybacs have shown that probiotics can help reduce these constipations and contribute to regular bowel movements2,3,8,9. Problems such as traveler's diarrhea, infections with E.coli or other bacteria could be effectively counteracted by certain bacterial strains4,6,10,12,14,15. There is an increased risk of the latter with regular intake of so-called Proton pump inhibitors (such asB Pantoprazole), which are prescribed for gastritis. Again, certain probiotic strains have been shown to be useful in restoring balance to the gastrointestinal tract7,11. The response of children with various intestinal complaints to treatment with probiotics4,12,14,15 was surprisingly good, but adults and older patients could also be helped very well. The safety of using probiotics was also considered and tested12. p. Del Piano, M., et al. (2010). The use of probiotics in healthy volunteers with evacuation disorders and hard stools: a double-blind, randomized, placebo-controlled study. Journal of clinical gastroenterology, 44, S30-S34. x. Del Piano, M., et al. (2008). In vitro sensitivity of probiotics to human pancreatic juice. Journal of clinical gastroenterology, 42, S170-S173. i. Mogna, L., et al. (2012). Assessment of the in vitro inhibitory activity of specific probiotic bacteria against different Escherichia coli strains. Journal of clinical gastroenterology, 46, S29-S32.h. Del Piano, M., et al. (2014). Correlation between chronic treatment with proton pump inhibitors and bacterial overgrowth in the stomach: any possible beneficial role for selected lactobacilli?. Journal of clinical gastroenterology, 48, S40-S46.
p. Del Piano, M., et al. (2010). The use of probiotics in healthy volunteers with evacuation disorders and hard stools: a double-blind, randomized, placebo-controlled study. Journal of clinical gastroenterology, 44, S30-S34. x. Del Piano, M., et al. (2008). In vitro sensitivity of probiotics to human pancreatic juice. Journal of clinical gastroenterology, 42, S170-S173. i. Mogna, L., et al. (2012). Assessment of the in vitro inhibitory activity of specific probiotic bacteria against different Escherichia coli strains. Journal of clinical gastroenterology, 46, S29-S32.h. Del Piano, M., et al. (2014). Correlation between chronic treatment with proton pump inhibitors and bacterial overgrowth in the stomach: any possible beneficial role for selected lactobacilli?. Journal of clinical gastroenterology, 48, S40-S46.
x. Del Piano, M., et al. (2008). In vitro sensitivity of probiotics to human pancreatic juice. Journal of clinical gastroenterology, 42, S170-S173.
i. Mogna, L., et al. (2012). Assessment of the in vitro inhibitory activity of specific probiotic bacteria against different Escherichia coli strains. Journal of clinical gastroenterology, 46, S29-S32.h. Del Piano, M., et al. (2014). Correlation between chronic treatment with proton pump inhibitors and bacterial overgrowth in the stomach: any possible beneficial role for selected lactobacilli?. Journal of clinical gastroenterology, 48, S40-S46.
A healthy cardiovascular system is important in order to be able to cope with everyday life, to feel fit and to be able to do sports. Especially with age, the topic "heart and circulation" comes more and more into focus, since hidden risks can lurk here. That is why it is crucial to take care of this system preventively and in good time. An important approach is weight management to achieve a healthy Body Mass Index (BMI). Studies have shown that inulin (from chicory root) can help with weight loss3. The onset of (pre-)diabetes could also be delayed2,3 and an anti-hyperglycaemic (against an elevated blood sugar level) effect could be determined2. Furthermore, studies have shown that the intake of polyphenols, e.g. contained in pomegranate, could support a reduction in cardiovascular risks1. Blood lipid balance is also important for cardiovascular health. If these are out of balance, e.g. if the level of “bad” cholesterol (LDL) is too high, this can have negative effects on the vascular system. Studies have shown that the inulin3 contained in the chicory root, but also certain strains of bacteria4, intervene in this system.
1. Noad, R.L., et al. (2016). Beneficial effect of a polyphenol-rich diet on cardiovascular risk: a randomized control trial. Heart, 102(17), 1371-1379.
2. Nishimura, M., et al. (2015). Effects of the extract from roasted chicory (Cichorium intybus L.) root containing inulin-type fructans on blood glucose, lipid metabolism, and fecal properties. Journal of traditional and complementary medicine, 5(3), 161-167.
3. Guess, N.D., et al. (2015). A randomized controlled trial: the effect of inulin on weight management and ectopic fat in subjects with prediabetes. Nutrition & metabolism, 12(1), 36.
4. Andrade, S., & Borges, N. (2009). Effect of fermented milk containing Lactobacillus acidophilus and Bifidobacterium longum on plasma lipids of women with normal or moderately elevated cholesterol. Journal of dairy research, 76(4), 469-474.
Research into the gut-brain axis has increasingly come into focus in recent years. Some studies have shown that the gut and our brain are closely connected and that a starting point can therefore also be found in the gut to create changes in the brain. Studies have tested the effect of inulin (found in chicory root) on perceived well-being, mood and cognitive performance3. It could be shown that the subjects' mood improved and they felt happier. In addition, an improvement in memory and retention was observed3. Studies on the use of probiotics for mental disorders have shown that taking certain strains of bacteria can lead to an improvement in various symptoms. On the one hand, an improvement in anxiety was observed in people with anxiety states1. Taking selected probiotics could also bring relief to patients with depression2. Furthermore, there are new approaches that want to further shed light on the microbiome and an imbalance in it in children with autism or the development of neuropsychiatric diseases. The exact mechanisms are still unclear, but a connection can already be identified4,5.
1. Huang, R., et al. (2017). Efficacy of probiotics on anxiety: A meta-analysis of randomized controlled trials. Neuropsychiatry, 7(6), 862-871.
2. Kim, C.S., & Shin, D.M. (2019). Probiotic food consumption is associated with lower severity and prevalence of depression: A nationwide cross-sectional study. Nutrition, 63, 169-174.
3. Smith, A., et al. (2015). An investigation of the acute effects of oligofructose-enriched inulin on subjective wellbeing, mood and cognitive performance. Nutrients, 7(11), 8887-8896.
4. Srikantha, P., & Mohajeri, M.H. (2019). The Possible Role of the Microbiota-Gut-Brain-Axis in Autism Spectrum Disorder. International journal of molecular sciences, 20(9), 2115.
5. Partty, A., et al. (2015). A possible link between early probiotic intervention and the risk of neuropsychiatric disorders later in childhood: a randomized trial. Pediatric research, 77(6), 823.
Studies have explored the direct effects of bacterial strains and polyphenols on body cells and their environment. Above all, an antioxidant effect was found1,2. This means a mechanism to capture free radical substances in the body and in the cells and thus render them "harmless". This can protect against diseases that are driven by so-called "oxidative stress". Confirmed and examined diseases are, for example, chronic inflammation, the metabolic syndrome (combination of obesity, diabetes, high blood pressure and increased blood lipid levels), high blood pressure and vascular damage with resulting cardiovascular risks and a risk of developing type 2 diabetes mellitus.
2. Kerimi, A., & Williamson, G. (2016). At the interface of antioxidant signaling and cellular function: key polyphenol effects. Molecular nutrition & food research, 60(8), 1770-1788.
Studies have tested the use of probiotics in the treatment and prevention of allergies. An immunomodulatory activity was found, which is seen as beneficial in asthma patients 1. A combination of bacterial strains and prebiotics was also able to show an effective effect against allergic rhinitis 2. Many studies investigated the effect of probiotics on the basis of allergies to Japanese pollen Cedar, which triggers allergic reactions in one in six Japanese. Here, too, probiotic bacteria were able to effectively improve the symptoms 4,5. Furthermore, studies have shown an advantage for the offspring when ingesting bifidobacteria by pregnant women and newborns. The development of allergies in the further course of life was examined, which could primarily be stopped by probiotics 3.
1. Drago, L., et al. (2015). Immunomodulatory effects of Lactobacillus salivarius LS01 and Bifidobacterium breve BR03, alone and in combination, on peripheral blood mononuclear cells of allergic asthmatics. Allergy, asthma & immunology research, 7(4), 409-413.
2. Manzotti, G., et al. (2014). Multi-strain Symbiotic Preparations as a Novel Adjuvant Approach to Allergic Rhinitis. Journal of Contemporary Immunology. 1. 67-80.
3. Enomoto, T., et al. (2014). Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergology International, 63(4), 575-585.
4. Xiao, J.Z., et al. (2006). Probiotics in the treatment of Japanese cedar pollinosis: a double-blind placebo-controlled trial. Clinical & Experimental Allergy, 36(11), 1425-1435.
5. Xiao, J.Z., et al. (2007). Clinical efficacy of probiotic Bifidobacterium longum for the treatment of symptoms of Japanese cedar pollen allergy in subjects evaluated in an environmental exposure unit. Allergology international, 56(1), 67-75.
The metabolism describes numerous processes that are constantly taking place in the body in order to maintain the functions of our cells. Studies have examined the effect of polyphenols (contained in e.g. pomegranate) on cells and cell mechanisms. The antidiabetic effect of polyphenols shown here has been used by physicians in traditional medicine for centuries. In these studies, the effectiveness of these substances against metabolic-associated diseases such as diabetes, obesity and subsequent complications could be examined here1. Polyphenols and their metabolites have the ability to reduce oxidative/inflammatory stress1 and protect against dysfunctional cells2. This has also been shown to improve skeletal muscle function2, including in aging individuals4. Furthermore, intensive research is being carried out into whether polyphenols and probiotic bacteria can have a positive effect on the growth of tumors (chemoprevention). The interaction with our intestinal bacteria is of crucial importance, as only they can convert the polyphenols into the active components3.
1. Les, F., et al. (2018). Pomegranate polyphenols and urolithin A inhibit α-glucosidase, dipeptidyl peptidase-4, lipase, triglyceride accumulation and adipogenesis related genes in 3T3-L1 adipocyte-like cells. Journal of ethnopharmacology, 220, 67-74.
2. Ryu, D., et al. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
3. Thilakarathna, W.W., et al. (2018). Polyphenol-based prebiotics and synbiotics: potential for cancer chemoprevention. Current Opinion in Food Science, 20, 51-57.
4. Andreux, P.A., et al. (2019). The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. Nature Metabolism, 1(6), 595.